Chemical Development Labs

Chemical Development Lab Infrastructure & Capabilities

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  • Four state-of-the-art laboratories equipped with 30 standard fumehoods
  • Each lab equipped with dedicated chilled water circulation, vacuum and inert gas lines.
  • Kilo lab with All Glass Assembly reactors (20 L, 50 L, 100 L), Operating temperature range from – 70 °C to +180 ° C
  • Rotary Evaporators (20 L, 50 L)
  • SS 316 Hydrogenator : 2 L, 5 L, Pressure up to 25 kg/cm2 and Temperature range 5 ° C to +180 ° C
  • Necessary supporting equipments like filtration, drying, sieving, Milling and Micronisation.

Capabilities

  • Synthetic Route Design & Scouting
  • Chemical Process Development using latest techniques
  • Large-scale chromatography
  • Process Engineering (Data Generation) & Process Safety Studies (Process Hazard Analysis)
  • Integrated Salt Screening, Polymorph studies, Crystallisation technologies
  • Impurity Profiling (including impurity & reference standard synthesis), CPP studies
  • Genotoxicity and Nitrosamine risk assessments and control strategies
  • Kilo & Pilot Scale Manufacturing
  • Process Validation followed by Commercial Manufacturing

Reaction Capabilities

  • Grignard reaction
  • Chiral Reduction
  • Chemical Resolution
  • Organometallic reaction
  • Alkylation
  • Acylation
  • Glycosidation
  • Carbonylation
  • Azide formation
  • Peptide coupling
  • Sugar chemistry
  • Oxidation
  • Enzymatic reduction
  • Suzuki coupling
  • Wittig Reaction
  • Cyanation
  • Halogenation
  • Nitration
  • Reductive Amination
  • Catalytic Hydrogenation
  • Condensation
  • Cyclization
  • Diazotization
  • Mesylation
  • Methylation
  • Demethylation
  • Photocatalytic reaction
  • Cryogenic reaction

Other capabilities include Purification of liquid product by high vacuum distillation, handling of gaseous reagents, high temperature reactions (250oC), handling of pyrophoric reagents and high-pressure reactions (250 PSI).

Literature support

  • Strong Chemistry database support from SciFinder and online search engines.
  • For patent search - Google Patents, Espacenet, USPTO Web Patent Database, Patentscope by WIPO, Lens.org, etc.,
  • For journals and other publications search - Google scholar, WorldWideScience, PubMed Central, Science.gov, Microsoft Academic, Bielefeld Academic Search Engine (BASE), etc.,